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Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a.
Zhang J, Bhuiyan MIH, Zhang T, Karimy JK, Wu Z, Fiesler VM, Zhang J, Huang H, Hasan MN, Skrzypiec AE, Mucha M, Duran D, Huang W, Pawlak R, Foley LM, Hitchens TK, Minnigh MB, Poloyac SM, Alper SL, Molyneaux BJ, Trevelyan AJ, Kahle KT, Sun D, Deng X. Zhang J, et al. Among authors: zhang t. Nat Commun. 2020 Jan 7;11(1):78. doi: 10.1038/s41467-019-13851-6. Nat Commun. 2020. PMID: 31911626 Free PMC article.
Characterization of TAE684 as a potent LRRK2 kinase inhibitor.
Zhang J, Deng X, Choi HG, Alessi DR, Gray NS. Zhang J, et al. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1864-9. doi: 10.1016/j.bmcl.2012.01.084. Epub 2012 Jan 28. Bioorg Med Chem Lett. 2012. PMID: 22335897 Free PMC article.
Brain Penetrant LRRK2 Inhibitor.
Choi HG, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS. Choi HG, et al. Among authors: zhang j. ACS Med Chem Lett. 2012 Aug 9;3(8):658-662. doi: 10.1021/ml300123a. Epub 2012 Jun 18. ACS Med Chem Lett. 2012. PMID: 23066449 Free PMC article.
Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.
Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, Ward C, Khanna AR, Mogil JS, Dion PA, Woolf CJ, Inquimbert P, Rouleau GA. Kahle KT, et al. Among authors: zhang j. Sci Signal. 2016 Mar 29;9(421):ra32. doi: 10.1126/scisignal.aad0163. Sci Signal. 2016. PMID: 27025876 Free PMC article.
164,942 results
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