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Discovery and Optimization of Seven-Membered Lactam-Based Compounds to Phenocopy the Inhibition of the Aurora Kinase B.
Huang J, Shi Q, Choudhry N, Li H, Yang C, Kalashova J, Yan Z, Li J, Reddy MC, Gopala SG, Zhang S, Zhang J, Nimishetti N, Yang D. Huang J, et al. Among authors: zhang s, zhang j. ACS Med Chem Lett. 2022 Jun 6;13(7):1091-1098. doi: 10.1021/acsmedchemlett.2c00098. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859866 Free PMC article.
2-Phenoxy-3, 4'-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization.
Lv G, Shi Q, Zhang T, Li J, Kalashova J, Long Y, Sun Y, Li C, Choudhry N, Li H, Yang C, Zhou X, Reddy MC, Anantoju KK, Jupelli R, Zhang S, Zhang J, Allen T, Liu H, Nimishetti N, Yang D. Lv G, et al. Among authors: zhang s, zhang t, zhang j. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114904. doi: 10.1016/j.ejmech.2022.114904. Epub 2022 Nov 8. Eur J Med Chem. 2023. PMID: 36413818
Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B.
Lv G, Shi Q, Zhang T, Li J, Long Y, Zhang W, Choudhry N, Yang K, Li H, Kalashova J, Yang C, Zhou X, Reddy MC, Anantoju KK, Zhang S, Zhang J, Allen TD, Liu H, Nimishetti N, Yang D. Lv G, et al. Among authors: zhang s, zhang w, zhang t, zhang j. Bioorg Med Chem. 2023 Feb 15;80:117173. doi: 10.1016/j.bmc.2023.117173. Epub 2023 Jan 16. Bioorg Med Chem. 2023. PMID: 36696874
Cyclic AMP-lowering mediator of insulin.
Zhang SR, Shi QH, Ho RJ. Zhang SR, et al. J Biol Chem. 1983 May 25;258(10):6471-6. J Biol Chem. 1983. PMID: 6304042 Free article.
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