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Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G. Hayashi Y, et al. Among authors: zhao x. Cancer Discov. 2018 Nov;8(11):1438-1457. doi: 10.1158/2159-8290.CD-17-1203. Epub 2018 Aug 23. Cancer Discov. 2018. PMID: 30139811 Free PMC article.
SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints.
Dong Y, Zhao X, Feng X, Zhou Y, Yan X, Zhang Y, Bu J, Zhan D, Hayashi Y, Zhang Y, Xu Z, Huang R, Wang J, Zhao T, Xiao Z, Ju Z, Andreassen PR, Wang QF, Chen W, Huang G. Dong Y, et al. Among authors: zhao x, zhao t. Leukemia. 2019 Nov;33(11):2585-2598. doi: 10.1038/s41375-019-0456-2. Epub 2019 Apr 9. Leukemia. 2019. PMID: 30967619 Free PMC article.
The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.
Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, Sashida G, Zhang Y, Liu Y, Lee J, Menendez S, Yang Y, Yan X, Zhang P, Tenen DG, Osato M, Hsieh JJ, Nimer SD. Huang G, et al. Among authors: zhao x. Blood. 2011 Dec 15;118(25):6544-52. doi: 10.1182/blood-2010-11-317909. Epub 2011 Oct 19. Blood. 2011. PMID: 22012064 Free PMC article.
Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.
Zhang Y, Yan X, Sashida G, Zhao X, Rao Y, Goyama S, Whitman SP, Zorko N, Bernot K, Conway RM, Witte D, Wang QF, Tenen DG, Xiao Z, Marcucci G, Mulloy JC, Grimes HL, Caligiuri MA, Huang G. Zhang Y, et al. Among authors: zhao x. Blood. 2012 Aug 2;120(5):1118-29. doi: 10.1182/blood-2012-02-412379. Epub 2012 Jun 26. Blood. 2012. PMID: 22740449 Free PMC article.
Creation of a six-fingered artificial transcription factor that represses the hepatitis B virus HBx gene integrated into a human hepatocellular carcinoma cell line.
Zhao X, Zhao Z, Guo J, Huang P, Zhu X, Zhou X, Yang Z, Zhao L, Xu L, Xu J, Fu L, Zhang J, Zhang X, Dong Y, Huang G, Wang Q, Li B, Song X, Yang X, Liu S, Yi S, Yu T, Yu C, Hou L, Li J, Chen W. Zhao X, et al. Among authors: zhao z, zhao l. J Biomol Screen. 2013 Apr;18(4):378-87. doi: 10.1177/1087057112463066. Epub 2012 Oct 5. J Biomol Screen. 2013. PMID: 23042077
CHIP functions an E3 ubiquitin ligase of Runx1.
Shang Y, Zhao X, Xu X, Xin H, Li X, Zhai Y, He D, Jia B, Chen W, Chang Z. Shang Y, et al. Among authors: zhao x. Biochem Biophys Res Commun. 2009 Aug 14;386(1):242-6. doi: 10.1016/j.bbrc.2009.06.043. Epub 2009 Jun 12. Biochem Biophys Res Commun. 2009. PMID: 19524548
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