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Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK. Xiao S, et al. Among authors: zhu c. J Exp Med. 2007 Jul 9;204(7):1691-702. doi: 10.1084/jem.20062498. Epub 2007 Jul 2. J Exp Med. 2007. PMID: 17606630 Free PMC article.
TIM-3 and its regulatory role in immune responses.
Zhu C, Anderson AC, Kuchroo VK. Zhu C, et al. Curr Top Microbiol Immunol. 2011;350:1-15. doi: 10.1007/82_2010_84. Curr Top Microbiol Immunol. 2011. PMID: 20700701 Review.
Aiolos promotes TH17 differentiation by directly silencing Il2 expression.
Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Quintana FJ, et al. Among authors: zhu c. Nat Immunol. 2012 Jul 1;13(8):770-7. doi: 10.1038/ni.2363. Nat Immunol. 2012. PMID: 22751139 Free PMC article.
Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.
Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Xiao S, et al. Among authors: zhu c. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12105-10. doi: 10.1073/pnas.1120914109. Epub 2012 Jul 5. Proc Natl Acad Sci U S A. 2012. PMID: 22773818 Free PMC article.
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