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RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.
Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. Deane R, et al. Among authors: zhu h. Nat Med. 2003 Jul;9(7):907-13. doi: 10.1038/nm890. Nat Med. 2003. PMID: 12808450
Neprilysin protects neurons against Abeta peptide toxicity.
El-Amouri SS, Zhu H, Yu J, Gage FH, Verma IM, Kindy MS. El-Amouri SS, et al. Among authors: zhu h. Brain Res. 2007 Jun 4;1152:191-200. doi: 10.1016/j.brainres.2007.03.072. Epub 2007 Mar 28. Brain Res. 2007. PMID: 17459354 Free PMC article.
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