Zhuang XX - Search Results

1

A synergized machine learning plus cross-species wet-lab validation approach identifies neuronal mitophagy inducers inhibiting Alzheimer disease.

Ai R, Zhuang XX, Anisimov A, Lu JH, Fang EF. Ai R, et al. Among authors: zhuang xx. Autophagy. 2022 Apr;18(4):939-941. doi: 10.1080/15548627.2022.2031382. Epub 2022 Feb 7. Autophagy. 2022. PMID: 35130128 Free PMC article.

2

Neuroprotective effects of baicalein in animal models of Parkinson's disease: A systematic review of experimental studies.

Zhu Q, Zhuang X, Lu J. Zhu Q, et al. Phytomedicine. 2019 Mar 1;55:302-309. doi: 10.1016/j.phymed.2018.09.215. Epub 2018 Sep 27. Phytomedicine. 2019. PMID: 30385133

3

Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.

Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, Lu JH, Yue Z. Lachance V, et al. Among authors: zhuang xx. Mol Neurodegener. 2019 Nov 27;14(1):43. doi: 10.1186/s13024-019-0342-4. Mol Neurodegener. 2019. PMID: 31775806 Free PMC article.

4

Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson's disease models.

Zhuang XX, Wang SF, Tan Y, Song JX, Zhu Z, Wang ZY, Wu MY, Cai CZ, Huang ZJ, Tan JQ, Su HX, Li M, Lu JH. Zhuang XX, et al. Cell Death Dis. 2020 Feb 18;11(2):128. doi: 10.1038/s41419-020-2322-6. Cell Death Dis. 2020. PMID: 32071296 Free PMC article.

5

NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation.

Cai CZ, Yang C, Zhuang XX, Yuan NN, Wu MY, Tan JQ, Song JX, Cheung KH, Su H, Wang YT, Tang BS, Behrends C, Durairajan SSK, Yue Z, Li M, Lu JH. Cai CZ, et al. Among authors: zhuang xx. Autophagy. 2021 May;17(5):1112-1130. doi: 10.1080/15548627.2020.1760623. Epub 2020 Jun 16. Autophagy. 2021. PMID: 32543313 Free PMC article.

6

Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models.

Zhu Q, Zhuang XX, Chen JY, Yuan NN, Chen Y, Cai CZ, Tan JQ, Su HX, Lu JH. Zhu Q, et al. Among authors: zhuang xx. Phytomedicine. 2021 Jul;87:153578. doi: 10.1016/j.phymed.2021.153578. Epub 2021 Apr 27. Phytomedicine. 2021. PMID: 34038839

7

Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.

Xie C, Zhuang XX, Niu Z, Ai R, Lautrup S, Zheng S, Jiang Y, Han R, Gupta TS, Cao S, Lagartos-Donate MJ, Cai CZ, Xie LM, Caponio D, Wang WW, Schmauck-Medina T, Zhang J, Wang HL, Lou G, Xiao X, Zheng W, Palikaras K, Yang G, Caldwell KA, Caldwell GA, Shen HM, Nilsen H, Lu JH, Fang EF. Xie C, et al. Among authors: zhuang xx. Nat Biomed Eng. 2022 Jan;6(1):76-93. doi: 10.1038/s41551-021-00819-5. Epub 2022 Jan 6. Nat Biomed Eng. 2022. PMID: 34992270 Free PMC article.

8

Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models.

Cai CZ, Zhuang XX, Zhu Q, Wu MY, Su H, Wang XJ, Iyaswamy A, Yue Z, Wang Q, Zhang B, Xue Y, Tan J, Li M, He H, Lu JH. Cai CZ, et al. Among authors: zhuang xx. Theranostics. 2022 Jan 24;12(4):1738-1755. doi: 10.7150/thno.64148. eCollection 2022. Theranostics. 2022. PMID: 35198070 Free PMC article.

9

Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms.

Dong Y, Zhuang XX, Wang YT, Tan J, Feng D, Li M, Zhong Q, Song Z, Shen HM, Fang EF, Lu JH. Dong Y, et al. Among authors: zhuang xx. Pharmacol Res. 2023 Aug;194:106835. doi: 10.1016/j.phrs.2023.106835. Epub 2023 Jun 20. Pharmacol Res. 2023. PMID: 37348691 Free article. Review.

10

Mechanistic insights into Qiteng Xiaozhuo Granules' regulation of autophagy for chronic glomerulonephritis treatment: Serum pharmacochemistry, network pharmacology, and experimental validation.

Liu T, Zhuang XX, Tang YY, Gao YC, Gao JR. Liu T, et al. Among authors: zhuang xx. J Ethnopharmacol. 2024 Apr 24;324:117819. doi: 10.1016/j.jep.2024.117819. Epub 2024 Jan 28. J Ethnopharmacol. 2024. PMID: 38286158

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