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Killing of Kras-mutant colon cancer cells via Rac-independent actin remodeling by the βGBP cytokine, a physiological PI3K inhibitor therapeutically effective in vivo.
Mallucci L, Shi DY, Davies D, Jordan P, Nicol A, Lotti L, Mariani-Costantini R, Verginelli F, Wells V, Zicha D. Mallucci L, et al. Among authors: zicha d. Mol Cancer Ther. 2012 Sep;11(9):1884-93. doi: 10.1158/1535-7163.MCT-11-1041-T. Epub 2012 Jul 2. Mol Cancer Ther. 2012. PMID: 22752425 Free PMC article.
Regulation of lymphatic-blood vessel separation by endothelial Rac1.
D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V, Martinez D, Aubyn D, Grose R, Thomas GJ, Spencer-Dene B, Zicha D, Davies D, Tybulewicz V, Hodivala-Dilke KM. D'Amico G, et al. Among authors: zicha d. Development. 2009 Dec;136(23):4043-53. doi: 10.1242/dev.035014. Development. 2009. PMID: 19906871 Free PMC article.
Evidence for protein 4.1B acting as a metastasis suppressor.
Cavanna T, Pokorná E, Veselý P, Gray C, Zicha D. Cavanna T, et al. Among authors: zicha d. J Cell Sci. 2007 Feb 15;120(Pt 4):606-16. doi: 10.1242/jcs.000273. Epub 2007 Jan 30. J Cell Sci. 2007. PMID: 17264155
63 results