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Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.
Gong L, Han X, Silva T, Tan YC, Goyal B, Tivitmahaisoon P, Trejo A, Palmer W, Hogg H, Jahagir A, Alam M, Wagner P, Stein K, Filonova L, Loe B, Makra F, Rotstein D, Rapatova L, Dunn J, Zuo F, Dal Porto J, Wong B, Jin S, Chang A, Tran P, Hsieh G, Niu L, Shao A, Reuter D, Hermann J, Kuglstatter A, Goldstein D. Gong L, et al. Among authors: zuo f. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3565-9. doi: 10.1016/j.bmcl.2013.04.029. Epub 2013 Apr 21. Bioorg Med Chem Lett. 2013. PMID: 23664880
Discovery of a novel series of 4-quinolone JNK inhibitors.
Gong L, Tan YC, Boice G, Abbot S, McCaleb K, Iyer P, Zuo F, Dal Porto J, Wong B, Jin S, Chang A, Tran P, Hsieh G, Niu L, Shao A, Reuter D, Lukacs CM, Ursula Kammlott R, Kuglstatter A, Goldstein D. Gong L, et al. Among authors: zuo f. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7381-7. doi: 10.1016/j.bmcl.2012.10.066. Epub 2012 Oct 24. Bioorg Med Chem Lett. 2012. PMID: 23142618
ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.
Gao G, Plaas A, Thompson VP, Jin S, Zuo F, Sandy JD. Gao G, et al. Among authors: zuo f. J Biol Chem. 2004 Mar 12;279(11):10042-51. doi: 10.1074/jbc.M312100200. Epub 2003 Dec 29. J Biol Chem. 2004. PMID: 14701864 Free article.
455 results