Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2018 1
2020 2
2021 2
2022 2
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

7 results

Results by year

Citations

1 article found by citation matching

Search results

Filters applied: . Clear all
Page 1
Dietary spermidine improves cognitive function.
Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Müller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Üçal M, Schäfer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Tölle RC, Sótonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Rácz B, Kiechl S, Eisenberg T, Madeo F. Schroeder S, et al. Cell Rep. 2021 Apr 13;35(2):108985. doi: 10.1016/j.celrep.2021.108985. Cell Rep. 2021. PMID: 33852843 Free article.
Neuron-specific Pink1 knockdown abolishes spermidine-induced improvement of olfactory associative learning. This suggests that the maintenance of mitochondrial and autophagic function is essential for enhanced cognition by spermidine feeding. Fi …
Neuron-specific Pink1 knockdown abolishes spermidine-induced improvement of olfactory associative learning. This suggests that …
Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging.
Hofer SJ, Liang Y, Zimmermann A, Schroeder S, Dengjel J, Kroemer G, Eisenberg T, Sigrist SJ, Madeo F. Hofer SJ, et al. Autophagy. 2021 Aug;17(8):2037-2039. doi: 10.1080/15548627.2021.1933299. Epub 2021 Jun 9. Autophagy. 2021. PMID: 34105442 Free PMC article. Review.
Importantly, externally supplied spermidine (via drinking water or food) prolongs lifespan, activates autophagy, improves mitochondrial function, and refills polyamine pools that decline during aging in various tissues of model organisms, including mice. In t …
Importantly, externally supplied spermidine (via drinking water or food) prolongs lifespan, activates autophagy, improves mito …
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
Schwarz C, Benson GS, Horn N, Wurdack K, Grittner U, Schilling R, Märschenz S, Köbe T, Hofer SJ, Magnes C, Stekovic S, Eisenberg T, Sigrist SJ, Schmitz D, Wirth M, Madeo F, Flöel A. Schwarz C, et al. JAMA Netw Open. 2022 May 2;5(5):e2213875. doi: 10.1001/jamanetworkopen.2022.13875. JAMA Netw Open. 2022. PMID: 35616942 Free PMC article. Clinical Trial.
IMPORTANCE: Developing interventions against age-related memory decline and for older adults experiencing neurodegenerative disease is one of the greatest challenges of our generation. Spermidine supplementation has shown beneficial effects on brain and cognitive he …
IMPORTANCE: Developing interventions against age-related memory decline and for older adults experiencing neurodegenerative disease is one o …
Effects of lifespan-extending interventions on cognitive healthspan.
Culig L, Sahbaz BD, Bohr VA. Culig L, et al. Expert Rev Mol Med. 2022 Nov 15;25:e2. doi: 10.1017/erm.2022.36. Expert Rev Mol Med. 2022. PMID: 36377361 Review.
Adding years to life and even to physical health is suboptimal or even insufficient, if cognitive ageing is not adequately improved. In this review, we will examine how interventions that have the potential to extend lifespan in animals affect the brain, and if they …
Adding years to life and even to physical health is suboptimal or even insufficient, if cognitive ageing is not adequately improve …
Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo.
Fischer M, Ruhnau J, Schulze J, Obst D, Flöel A, Vogelgesang A. Fischer M, et al. Aging (Albany NY). 2020 Jun 30;12(13):13716-13739. doi: 10.18632/aging.103527. Epub 2020 Jun 30. Aging (Albany NY). 2020. PMID: 32603310 Free PMC article.
The global increase in neurodegenerative disorders is one of the most crucial public health issues. Oral polyamine intake was shown to improve memory performance which is thought to be mediated at least in part via increased autophagy induced in brain cells. ...Although ef …
The global increase in neurodegenerative disorders is one of the most crucial public health issues. Oral polyamine intake was shown to im …
The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways.
Yang Y, Zhang L. Yang Y, et al. Food Funct. 2020 Feb 26;11(2):1211-1224. doi: 10.1039/c9fo02611h. Food Funct. 2020. PMID: 32068753 Review.
Alzheimer's disease (AD) is a neurodegenerative disorder that commonly occurs among older individuals. Increasing evidence suggests that a low-caloric diet might be a promising adjuvant therapeutic strategy for slowing or preventing the pathogenesis and progression of AD t …
Alzheimer's disease (AD) is a neurodegenerative disorder that commonly occurs among older individuals. Increasing evidence suggests that a l …
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.
Wirth M, Benson G, Schwarz C, Köbe T, Grittner U, Schmitz D, Sigrist SJ, Bohlken J, Stekovic S, Madeo F, Flöel A. Wirth M, et al. Cortex. 2018 Dec;109:181-188. doi: 10.1016/j.cortex.2018.09.014. Epub 2018 Oct 4. Cortex. 2018. PMID: 30388439 Clinical Trial.
METHODS: Cognitively intact participants with subjective cognitive decline (n = 30, 60-80 years of age) were included in this three-months, randomized, placebo-controlled, double-blind Phase IIa pilot trial with a spermidine-rich plant extract supplement. ...Mnemoni …
METHODS: Cognitively intact participants with subjective cognitive decline (n = 30, 60-80 years of age) were included in this three-m …