Abstract
Adoptive transfer of bone marrow cells from tuberculosis-resistant (I/St x A/Sn)F(1) donor mice into lethally irradiated susceptible I/St recipients changed their phenotype following infection with virulent Mycobacterium tuberculosis. Compared to I/St-->I/St control animals, F(1)-->I/St chimeras demonstrated (i) prolonged survival time, (ii) increased antimycobacterial function of lung macrophages, (iii) elevated gamma interferon production by lung cells, and (iv) decreased infiltration of the lungs with CD4(+) and CD8(+) T cells and Ly-6G(+) neutrophils.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adoptive Transfer
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Animals
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Bone Marrow Cells / immunology*
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Bone Marrow Transplantation / immunology
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Bone Marrow Transplantation / pathology
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Female
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Genetic Predisposition to Disease*
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Immunophenotyping
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Lung / immunology
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Lung / microbiology
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Lung / pathology
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Mice
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Mice, Inbred A
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Phenotype*
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Radiation Chimera*
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Tuberculosis, Pulmonary / genetics*
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Tuberculosis, Pulmonary / immunology*
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Tuberculosis, Pulmonary / mortality
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Tuberculosis, Pulmonary / pathology