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Page 1
Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase.
Bioorg Med Chem Lett. 2011 Jul 1;21(13):4066-71. doi: 10.1016/j.bmcl.2011.04.121. Epub 2011 May 11.
Bioorg Med Chem Lett. 2011.
PMID: 21641211
Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase.
Selness SR, Devraj RV, Monahan JB, Boehm TL, Walker JK, Devadas B, Durley RC, Kurumbail R, Shieh H, Xing L, Hepperle M, Rucker PV, Jerome KD, Benson AG, Marrufo LD, Madsen HM, Hitchcock J, Owen TJ, Christie L, Promo MA, Hickory BS, Alvira E, Naing W, Blevis-Bal R.
Selness SR, et al. Among authors: durley rc.
Bioorg Med Chem Lett. 2009 Oct 15;19(20):5851-6. doi: 10.1016/j.bmcl.2009.08.082. Epub 2009 Aug 27.
Bioorg Med Chem Lett. 2009.
PMID: 19751974
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Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein.
Durley RC, Grapperhaus ML, Hickory BS, Massa MA, Wang JL, Spangler DP, Mischke DA, Parnas BL, Fobian YM, Rath NP, Honda DD, Zeng M, Connolly DT, Heuvelman DM, Witherbee BJ, Melton MA, Glenn KC, Krul ES, Smith ME, Sikorski JA.
Durley RC, et al.
J Med Chem. 2002 Aug 29;45(18):3891-904. doi: 10.1021/jm020038h.
J Med Chem. 2002.
PMID: 12190312
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Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase.
Selness SR, Boehm TL, Walker JK, Devadas B, Durley RC, Kurumbail R, Shieh H, Xing L, Hepperle M, Rucker PV, Jerome KD, Benson AG, Marrufo LD, Madsen HM, Hitchcock J, Owen TJ, Christie L, Promo MA, Hickory BS, Alvira E, Naing W, Blevis-Bal R, Devraj RV, Messing D, Schindler JF, Hirsch J, Saabye M, Bonar S, Webb E, Anderson G, Monahan JB.
Selness SR, et al. Among authors: durley rc.
Bioorg Med Chem Lett. 2011 Jul 1;21(13):4059-65. doi: 10.1016/j.bmcl.2011.04.120. Epub 2011 May 13.
Bioorg Med Chem Lett. 2011.
PMID: 21640588
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Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein.
Reinhard EJ, Wang JL, Durley RC, Fobian YM, Grapperhaus ML, Hickory BS, Massa MA, Norton MB, Promo MA, Tollefson MB, Vernier WF, Connolly DT, Witherbee BJ, Melton MA, Regina KJ, Smith ME, Sikorski JA.
Reinhard EJ, et al. Among authors: durley rc.
J Med Chem. 2003 May 22;46(11):2152-68. doi: 10.1021/jm020528+.
J Med Chem. 2003.
PMID: 12747787
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