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First-in-human Phase I studies of PRS-080#22, a hepcidin antagonist, in healthy volunteers and patients with chronic kidney disease undergoing hemodialysis.
Renders L, Budde K, Rosenberger C, van Swelm R, Swinkels D, Dellanna F, Feuerer W, Wen M, Erley C, Bader B, Sommerer C, Schaier M, Meurer K, Matis L. Renders L, et al. Among authors: van swelm r. PLoS One. 2019 Mar 27;14(3):e0212023. doi: 10.1371/journal.pone.0212023. eCollection 2019. PLoS One. 2019. PMID: 30917125 Free PMC article. Clinical Trial.
Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey.
Hohlbaum AM, Gille H, Trentmann S, Kolodziejczyk M, Rattenstetter B, Laarakkers CM, Katzmann G, Christian HJ, Andersen N, Allersdorfer A, Olwill SA, Meibohm B, Audoly LP, Swinkels DW, van Swelm RPL. Hohlbaum AM, et al. Br J Pharmacol. 2018 Apr;175(7):1054-1065. doi: 10.1111/bph.14143. Epub 2018 Feb 23. Br J Pharmacol. 2018. PMID: 29329501 Free PMC article.
The multifaceted role of iron in renal health and disease.
van Swelm RPL, Wetzels JFM, Swinkels DW. van Swelm RPL, et al. Nat Rev Nephrol. 2020 Feb;16(2):77-98. doi: 10.1038/s41581-019-0197-5. Epub 2019 Sep 25. Nat Rev Nephrol. 2020. PMID: 31554933 Review.
Mass spectrometry analysis of hepcidin peptides in experimental mouse models.
Tjalsma H, Laarakkers CM, van Swelm RP, Theurl M, Theurl I, Kemna EH, van der Burgt YE, Venselaar H, Dutilh BE, Russel FG, Weiss G, Masereeuw R, Fleming RE, Swinkels DW. Tjalsma H, et al. Among authors: van swelm rp, van der burgt ye. PLoS One. 2011 Mar 8;6(3):e16762. doi: 10.1371/journal.pone.0016762. PLoS One. 2011. PMID: 21408141 Free PMC article.
36 results