van der Neut MA - Search Results

1

Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: design, synthesis, structure-activity relationships, physicochemical properties and biological activity.

Blaazer AR, Lange JH, van der Neut MA, Mulder A, den Boon FS, Werkman TR, Kruse CG, Wadman WJ. Blaazer AR, et al. Among authors: van der neut ma. Eur J Med Chem. 2011 Oct;46(10):5086-98. doi: 10.1016/j.ejmech.2011.08.021. Epub 2011 Aug 23. Eur J Med Chem. 2011. PMID: 21885167

2

Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists.

Lange JH, den Hartog AP, van der Neut MA, van Vliet BJ, Kruse CG. Lange JH, et al. Among authors: van vliet bj, van der neut ma. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5675-8. doi: 10.1016/j.bmcl.2009.08.007. Epub 2009 Aug 7. Bioorg Med Chem Lett. 2009. PMID: 19699640

3

Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies.

Lange JH, van der Neut MA, Wals HC, Kuil GD, Borst AJ, Mulder A, den Hartog AP, Zilaout H, Goutier W, van Stuivenberg HH, van Vliet BJ. Lange JH, et al. Among authors: van der neut ma. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1084-9. doi: 10.1016/j.bmcl.2009.12.032. Epub 2009 Dec 11. Bioorg Med Chem Lett. 2010. PMID: 20031412

4

Design, synthesis, biological properties, and molecular modeling investigations of novel tacrine derivatives with a combination of acetylcholinesterase inhibition and cannabinoid CB1 receptor antagonism.

Lange JH, Coolen HK, van der Neut MA, Borst AJ, Stork B, Verveer PC, Kruse CG. Lange JH, et al. Among authors: van der neut ma. J Med Chem. 2010 Feb 11;53(3):1338-46. doi: 10.1021/jm901614b. J Med Chem. 2010. PMID: 20047331

5

Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB(1) receptor antagonists.

Lange JH, van der Neut MA, den Hartog AP, Wals HC, Hoogendoorn J, van Stuivenberg HH, van Vliet BJ, Kruse CG. Lange JH, et al. Among authors: van der neut ma. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1752-7. doi: 10.1016/j.bmcl.2010.01.049. Epub 2010 Jan 20. Bioorg Med Chem Lett. 2010. PMID: 20137935

6

Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern.

Lange JH, van der Neut MA, Borst AJ, Yildirim M, van Stuivenberg HH, van Vliet BJ, Kruse CG. Lange JH, et al. Among authors: van der neut ma. Bioorg Med Chem Lett. 2010 May 1;20(9):2770-5. doi: 10.1016/j.bmcl.2010.03.068. Epub 2010 Mar 19. Bioorg Med Chem Lett. 2010. PMID: 20363132

7

Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists.

Lange JH, Attali A, van der Neut MA, Wals HC, Mulder A, Zilaout H, Duursma A, van Aken HH, van Vliet BJ. Lange JH, et al. Among authors: van der neut ma. Bioorg Med Chem Lett. 2010 Sep 1;20(17):4992-8. doi: 10.1016/j.bmcl.2010.07.056. Epub 2010 Jul 17. Bioorg Med Chem Lett. 2010. PMID: 20688519

8

N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT₆R) antagonists with unique structural features.

van Loevezijn A, Venhorst J, Iwema Bakker WI, de Korte CG, de Looff W, Verhoog S, van Wees JW, van Hoeve M, van de Woestijne RP, van der Neut MA, Borst AJ, van Dongen MJ, de Bruin NM, Keizer HG, Kruse CG. van Loevezijn A, et al. Among authors: van der neut ma. J Med Chem. 2011 Oct 27;54(20):7030-54. doi: 10.1021/jm200466r. Epub 2011 Sep 26. J Med Chem. 2011. PMID: 21866910

9

Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket.

van Loevezijn A, Venhorst J, Iwema Bakker WI, Lange JHM, de Looff W, Henzen R, de Vries J, van de Woestijne RP, den Hartog AP, Verhoog S, van der Neut MAW, de Bruin NMWJ, Kruse CG. van Loevezijn A, et al. Among authors: van der neut maw. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1605-1611. doi: 10.1016/j.bmcl.2016.02.001. Epub 2016 Feb 2. Bioorg Med Chem Lett. 2016. PMID: 26876931

10

7-Azaindole derivatives as potential partial nicotinic agonists.

Stoit AR, den Hartog AP, Mons H, van Schaik S, Barkhuijsen N, Stroomer C, Coolen HK, Reinders JH, Adolfs TJ, van der Neut M, Keizer H, Kruse CG. Stoit AR, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):188-93. doi: 10.1016/j.bmcl.2007.10.101. Epub 2007 Nov 1. Bioorg Med Chem Lett. 2008. PMID: 18006307

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