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Synthesis of novel PPARα/γ dual agonists as potential drugs for the treatment of the metabolic syndrome and diabetes type II designed using a new de novo design program PROTOBUILD.
Bhurruth-Alcor Y, Røst T, Jorgensen MR, Kontogiorgis C, Skorve J, Cooper RG, Sheridan JM, Hamilton WD, Heal JR, Berge RK, Miller AD. Bhurruth-Alcor Y, et al. Org Biomol Chem. 2011 Feb 21;9(4):1169-88. doi: 10.1039/c0ob00146e. Epub 2010 Dec 15. Org Biomol Chem. 2011. PMID: 21157612