Leucine supplementation combined with resistance exercise improves the plasma lipid profile of dexamethasone-treated rats

Humberto Nicastro; Claudia R da Luz; Daniela F S Chaves; William das Neves; Kerolyn S Valente; Antonio H Lancha Jr

doi:10.1186/1476-511X-11-7

Leucine supplementation combined with resistance exercise improves the plasma lipid profile of dexamethasone-treated rats

Lipids Health Dis. 2012 Jan 11:11:7. doi: 10.1186/1476-511X-11-7.

Authors

Humberto Nicastro¹, Claudia R da Luz, Daniela F S Chaves, William das Neves, Kerolyn S Valente, Antonio H Lancha Jr

Affiliation

¹ Laboratory of Applied Nutrition and Metabolism, Physical Education and Sports School, University of São Paulo - São Paulo, SP, Brazil. nicastro@usp.br

Abstract

The impact of leucine supplementation and resistance exercise (RE) on plasma lipid profile was evaluated in adult rats treated with dexamethasone, an experimental model of dyslipidemia. Total cholesterol did not differ among groups. Furthermore, leucine supplementation did not promote improvement in the plasma total cholesterol and LDL-c of the animals. However, plasma TG and VLDL-c were significantly decreased and HDL-c increased after 7 days of leucine supplementation combined with RE. In conclusion, leucine supplementation combined with RE, but not isolated, improved the plasma lipid profile of dexamethasone-induced dyslipidemic rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dexamethasone
Dietary Supplements*
Dyslipidemias / chemically induced
Dyslipidemias / drug therapy
Hypolipidemic Agents / pharmacology
Hypolipidemic Agents / therapeutic use*
Leucine / pharmacology
Leucine / therapeutic use*
Lipids / blood*
Male
Rats
Rats, Wistar
Resistance Training*

Substances

Hypolipidemic Agents
Lipids
Dexamethasone
Leucine