Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2012 1
2014 1
2017 2
2018 2
2019 1
2020 4
2021 4
2023 2
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

14 results

Results by year

Filters applied: . Clear all
Page 1
Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-beta Signaling Pathways via Integrins.
Huang Y, Zhao H, Zhang Y, Tang Y, Shi X, Jiang S, Pu W, Liu J, Ma Y, Lin J, Lin J, Wu W, Gong Y, Wang J, Liu Q. Huang Y, et al. Int J Biol Sci. 2023 Apr 29;19(8):2394-2408. doi: 10.7150/ijbs.77649. eCollection 2023. Int J Biol Sci. 2023. PMID: 37215989 Free PMC article.
Moreover, we found Zyxin inhibition could significantly alleviate skin fibrosis using Zyxin knock-down and knock-out mice, nude mouse model and skin explants of human keloid. Double immunofluorescence staining showed that Zyxin was highly expressed in fibrobl …
Moreover, we found Zyxin inhibition could significantly alleviate skin fibrosis using Zyxin knock-down and knock-out mice, nud …
Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway.
Cai T, Bai J, Tan P, Huang Z, Liu C, Wu Z, Cheng Y, Li T, Chen Y, Ruan J, Gao L, DU Y, Fu W. Cai T, et al. Among authors: huang z. Oncol Res. 2023 Jul 21;31(5):805-817. doi: 10.32604/or.2023.029549. eCollection 2023. Oncol Res. 2023. PMID: 37547758 Free PMC article.
The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin (ZYX) in HCC. We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues. ...
The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin (ZYX) in HCC. We foun …
Variants of Focal Adhesion Scaffold Genes Cause Thoracic Aortic Aneurysm.
Li Y, Gao S, Han Y, Song L, Kong Y, Jiao Y, Huang S, Du J, Li Y. Li Y, et al. Among authors: huang s. Circ Res. 2021 Jan 8;128(1):8-23. doi: 10.1161/CIRCRESAHA.120.317361. Epub 2020 Oct 23. Circ Res. 2021. PMID: 33092471 Free article.
Interestingly, suspected functional variants of other focal adhesion scaffold genes, including TLN1 (Talin-1) and ZYX (zyxin), were also significantly enriched in patients with iTAA; moreover, their knockdown resulted in decreased contractility of vascular smooth muscle ce …
Interestingly, suspected functional variants of other focal adhesion scaffold genes, including TLN1 (Talin-1) and ZYX (zyxin), were a …
Increased Expression of Zyxin and Its Potential Function in Androgenetic Alopecia.
Liu Q, Shi X, Zhang Y, Huang Y, Yang K, Tang Y, Ma Y, Zhang Y, Wang J, Zhang L, Zhang Q, Liu X, Lin J, Wang J, Wu W. Liu Q, et al. Among authors: huang y. Front Cell Dev Biol. 2021 Jan 11;8:582282. doi: 10.3389/fcell.2020.582282. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33505959 Free PMC article.
Previous studies have revealed that adhesion signals are important factors in AGA development. Zyxin (ZYX) is an actin-interacting protein that is essential for cell adhesion and migration. ...
Previous studies have revealed that adhesion signals are important factors in AGA development. Zyxin (ZYX) is an actin-interacting pr …
Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules.
Han X, Li P, Yang Z, Huang X, Wei G, Sun Y, Kang X, Hu X, Deng Q, Chen L, He A, Huo Y, Li D, Betzig E, Luo J. Han X, et al. Among authors: huang x. Nat Commun. 2017 Mar 3;8:14639. doi: 10.1038/ncomms14639. Nat Commun. 2017. PMID: 28256511 Free PMC article.
Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF. ...Our findings identify zyxin as a physiological regulator of endothelial exocytosis through reo …
Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defe …
Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme.
Wen XM, Luo T, Jiang Y, Wang LH, Luo Y, Chen Q, Yang K, Yuan Y, Luo C, Zhang X, Yan ZX, Fu WJ, Tan YH, Niu Q, Xiao JF, Chen L, Wang J, Huang JF, Cui YH, Zhang X, Wang Y, Bian XW. Wen XM, et al. Among authors: huang jf. Lab Invest. 2020 Jun;100(6):812-823. doi: 10.1038/s41374-019-0368-9. Epub 2020 Jan 16. Lab Invest. 2020. PMID: 31949244 Free article.
Since cytoskeleton proteins are related to leading processes and cell motility, and through analysis of public GBM databases, we determined that an actin-interacting protein, zyxin (ZYX), may involved in GBM invasion. Our own glioma cohort as well as the cancer genome atla …
Since cytoskeleton proteins are related to leading processes and cell motility, and through analysis of public GBM databases, we determined …
Zyxin is involved in regulation of mechanotransduction in arteriole smooth muscle cells.
Sun Z, Huang S, Li Z, Meininger GA. Sun Z, et al. Among authors: huang s. Front Physiol. 2012 Dec 20;3:472. doi: 10.3389/fphys.2012.00472. eCollection 2012. Front Physiol. 2012. PMID: 23267329 Free PMC article.
Whereas, reduction of zyxin expression by using a zyxin-shRNA construct abolished the VSMC contractile response to AFM pulling forces, even though the zyxin-silenced VSMCs displayed increased adhesion to FN in both AFM adhesion assays and cell adhesion assays …
Whereas, reduction of zyxin expression by using a zyxin-shRNA construct abolished the VSMC contractile response to AFM pulling …
Synergism between the phosphatidylinositol 3-kinase p110β isoform inhibitor AZD6482 and the mixed lineage kinase 3 inhibitor URMC-099 on the blockade of glioblastoma cell motility and focal adhesion formation.
Zhao HF, Wu CP, Zhou XM, Diao PY, Xu YW, Liu J, Wang J, Huang XJ, Liu WL, Chen ZP, Huang GD, Li WP. Zhao HF, et al. Among authors: huang xj, huang gd. Cancer Cell Int. 2021 Jan 6;21(1):24. doi: 10.1186/s12935-020-01728-4. Cancer Cell Int. 2021. PMID: 33407478 Free PMC article.
Glioblastoma cells treated with this drug combination showed reduced phosphorylation of Akt and ERK, and decreased protein expression of ROCK2 and Zyxin. CONCLUSION: Taken together, combination of AZD6482 and URMC-099 showed strong synergistic anti-tumor effects on gliobla …
Glioblastoma cells treated with this drug combination showed reduced phosphorylation of Akt and ERK, and decreased protein expression of ROC …
Anti-Adhesion Behavior from Ring-Strain Amine Cyclic Monolayers Grafted on Silicon (111) Surfaces.
Ching JY, Huang BJ, Hsu YT, Khung YL. Ching JY, et al. Among authors: huang bj. Sci Rep. 2020 May 29;10(1):8758. doi: 10.1038/s41598-020-65710-w. Sci Rep. 2020. PMID: 32472042 Free PMC article.
The expression level of focal adhesion proteins (vinculin, paxilin, talin and zyxin) were subsequently quantified for all three cell types via qPCR analysis. ...
The expression level of focal adhesion proteins (vinculin, paxilin, talin and zyxin) were subsequently quantified for all three cell …
Myosin IIa is critical for cAMP-mediated endothelial secretion of von Willebrand factor.
Li P, Wei G, Cao Y, Deng Q, Han X, Huang X, Huo Y, He Y, Chen L, Luo J. Li P, et al. Among authors: huang x. Blood. 2018 Feb 8;131(6):686-698. doi: 10.1182/blood-2017-08-802140. Epub 2017 Dec 5. Blood. 2018. PMID: 29208598 Free article.
Further study showed that in resting cells, myosin IIa deficiency disrupted the peripheral localization of Rab27-positive WPBs along stress fibers; on stimulation by cAMP agonists, myosin IIa in synergy with zyxin promotes the formation of a functional actin framework, whi …
Further study showed that in resting cells, myosin IIa deficiency disrupted the peripheral localization of Rab27-positive WPBs along stress …
14 results