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The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.
Gene. 2000 Jun 13;251(1):81-90. doi: 10.1016/s0378-1119(00)00171-2.
Gene. 2000.
PMID: 10863099
Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the NIH (AI20264 to H.G.F.).
Lowden PA, Wilkinson B, Böhm GA, Handa S, Floss HG, Leadlay PF, Staunton J.
Lowden PA, et al.
Angew Chem Int Ed Engl. 2001 Feb 16;40(4):777-779.
Angew Chem Int Ed Engl. 2001.
PMID: 11241621
No abstract available.
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