Abstract
A gene encoding a transport protein from the pathogenic yeast, Candida albicans, has been isolated during a complementation experiment utilizing an ornithine decarboxylase-negative (spe1 Delta) strain of Saccharomyces cerevisiae. This gene restores gamma-aminobutyric acid (GABA) transport to a GABA transport-negative mutant of S. cerevisiae and encodes a protein which putatively allows transport of one or more of the polyamines. We have assigned the name GPT1 (GABA/polyamine transporter) to this gene.
Copyright 2001 John Wiley & Sons, Ltd.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Candida albicans / enzymology
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Candida albicans / genetics*
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Candida albicans / growth & development
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Carrier Proteins / genetics*
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Carrier Proteins / metabolism
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Fungal Proteins*
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GABA Plasma Membrane Transport Proteins
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Gene Library
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Genes, Fungal*
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Genetic Complementation Test
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Membrane Transport Proteins*
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Molecular Sequence Data
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Organic Anion Transporters*
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Ornithine Decarboxylase / genetics
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Ornithine Decarboxylase / metabolism
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Polyamines / metabolism
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Saccharomyces cerevisiae Proteins
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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gamma-Aminobutyric Acid / physiology
Substances
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Carrier Proteins
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Fungal Proteins
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GABA Plasma Membrane Transport Proteins
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GPT1 protein, Candida albicans
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Membrane Proteins
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Membrane Transport Proteins
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Organic Anion Transporters
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Polyamines
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Saccharomyces cerevisiae Proteins
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UGA4 protein, S cerevisiae
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gamma-Aminobutyric Acid
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Ornithine Decarboxylase