15703303,15924421,16878979,17327228,17379813,17655326,18061070,18621017,19506075,22079344,25845827,28219011,32480173 - Search Results

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Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity.

Ma Z, Jiang L, Li G, Liang D, Li L, Liu L, Jiang C. Ma Z, et al. Bioorg Chem. 2020 Aug;101:103971. doi: 10.1016/j.bioorg.2020.103971. Epub 2020 May 25. Bioorg Chem. 2020. PMID: 32480173

Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.

Buchman CD, Hurley TD. Buchman CD, et al. J Med Chem. 2017 Mar 23;60(6):2439-2455. doi: 10.1021/acs.jmedchem.6b01825. Epub 2017 Mar 6. J Med Chem. 2017. PMID: 28219011 Free PMC article.

A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834.

Sodhi JK, Wong S, Kirkpatrick DS, Liu L, Khojasteh SC, Hop CE, Barr JT, Jones JP, Halladay JS. Sodhi JK, et al. Drug Metab Dispos. 2015 Jun;43(6):908-15. doi: 10.1124/dmd.114.061804. Epub 2015 Apr 6. Drug Metab Dispos. 2015. PMID: 25845827 Free PMC article.

The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance.

Moreb JS, Ucar D, Han S, Amory JK, Goldstein AS, Ostmark B, Chang LJ. Moreb JS, et al. Chem Biol Interact. 2012 Jan 5;195(1):52-60. doi: 10.1016/j.cbi.2011.10.007. Epub 2011 Nov 3. Chem Biol Interact. 2012. PMID: 22079344 Free PMC article.

Role of the general base Glu-268 in nitroglycerin bioactivation and superoxide formation by aldehyde dehydrogenase-2.

Wenzl MV, Beretta M, Gorren AC, Zeller A, Baral PK, Gruber K, Russwurm M, Koesling D, Schmidt K, Mayer B. Wenzl MV, et al. J Biol Chem. 2009 Jul 24;284(30):19878-86. doi: 10.1074/jbc.M109.005652. Epub 2009 Jun 8. J Biol Chem. 2009. PMID: 19506075 Free PMC article.

Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1.

Glatt H, Rost K, Frank H, Seidel A, Kollock R. Glatt H, et al. Arch Biochem Biophys. 2008 Sep 15;477(2):196-205. doi: 10.1016/j.abb.2008.06.020. Epub 2008 Jun 28. Arch Biochem Biophys. 2008. PMID: 18621017

Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels.

Hink U, Daiber A, Kayhan N, Trischler J, Kraatz C, Oelze M, Mollnau H, Wenzel P, Vahl CF, Ho KK, Weiner H, Munzel T. Hink U, et al. J Am Coll Cardiol. 2007 Dec 4;50(23):2226-32. doi: 10.1016/j.jacc.2007.08.031. Epub 2007 Nov 19. J Am Coll Cardiol. 2007. PMID: 18061070 Free article. Clinical Trial.

Mechanistic implications of the cysteine-nicotinamide adduct in aldehyde dehydrogenase based on quantum mechanical/molecular mechanical simulations.

Wymore T, Deerfield DW 2nd, Hempel J. Wymore T, et al. Biochemistry. 2007 Aug 21;46(33):9495-506. doi: 10.1021/bi700555g. Epub 2007 Jul 27. Biochemistry. 2007. PMID: 17655326 Free PMC article.

Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase.

Marchitti SA, Deitrich RA, Vasiliou V. Marchitti SA, et al. Pharmacol Rev. 2007 Jun;59(2):125-50. doi: 10.1124/pr.59.2.1. Epub 2007 Mar 22. Pharmacol Rev. 2007. PMID: 17379813 Review.

Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487.

Larson HN, Zhou J, Chen Z, Stamler JS, Weiner H, Hurley TD. Larson HN, et al. J Biol Chem. 2007 Apr 27;282(17):12940-50. doi: 10.1074/jbc.M607959200. Epub 2007 Feb 27. J Biol Chem. 2007. PMID: 17327228 Free PMC article.

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