Abstract
Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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Drug Design
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Hydro-Lyases / antagonists & inhibitors*
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Models, Molecular
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Molecular Conformation
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Protein Conformation
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Stereoisomerism
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Streptomyces coelicolor / enzymology
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Hydro-Lyases
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3-dehydroquinate dehydratase