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Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the "oxaloacetate-inhibited" state.
Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1073-83. doi: 10.1016/j.bbabio.2006.06.015. Epub 2006 Jul 12.
Biochim Biophys Acta. 2006.
PMID: 16935256
Free PMC article.
3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.
Huang LS, Sun G, Cobessi D, Wang AC, Shen JT, Tung EY, Anderson VE, Berry EA.
Huang LS, et al.
J Biol Chem. 2006 Mar 3;281(9):5965-72. doi: 10.1074/jbc.M511270200. Epub 2005 Dec 21.
J Biol Chem. 2006.
PMID: 16371358
Free PMC article.
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