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Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding.
Biochemistry. 2008 Oct 7;47(40):10677-84. doi: 10.1021/bi801202a. Epub 2008 Sep 11.
Biochemistry. 2008.
PMID: 18783250
Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase.
Forouhar F, Anderson JL, Mowat CG, Vorobiev SM, Hussain A, Abashidze M, Bruckmann C, Thackray SJ, Seetharaman J, Tucker T, Xiao R, Ma LC, Zhao L, Acton TB, Montelione GT, Chapman SK, Tong L.
Forouhar F, et al.
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):473-8. doi: 10.1073/pnas.0610007104. Epub 2006 Dec 29.
Proc Natl Acad Sci U S A. 2007.
PMID: 17197414
Free PMC article.
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