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A single mutation in the active site swaps the substrate specificity of N-acetyl-L-ornithine transcarbamylase and N-succinyl-L-ornithine transcarbamylase.
Protein Sci. 2007 Aug;16(8):1689-99. doi: 10.1110/ps.072919907. Epub 2007 Jun 28.
Protein Sci. 2007.
PMID: 17600144
Free PMC article.
Structure and catalytic mechanism of a novel N-succinyl-L-ornithine transcarbamylase in arginine biosynthesis of Bacteroides fragilis.
Shi D, Morizono H, Cabrera-Luque J, Yu X, Roth L, Malamy MH, Allewell NM, Tuchman M.
Shi D, et al.
J Biol Chem. 2006 Jul 21;281(29):20623-31. doi: 10.1074/jbc.M601229200. Epub 2006 May 16.
J Biol Chem. 2006.
PMID: 16704984
Free article.
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