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The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: unambiguous resolution of the stereochemistry of the condensation product.
Proteins. 2012 Aug;80(8):2117-22. doi: 10.1002/prot.24106. Epub 2012 Jun 4.
Proteins. 2012.
PMID: 22552955
How essential is the 'essential' active-site lysine in dihydrodipicolinate synthase?
Soares da Costa TP, Muscroft-Taylor AC, Dobson RC, Devenish SR, Jameson GB, Gerrard JA.
Soares da Costa TP, et al.
Biochimie. 2010 Jul;92(7):837-45. doi: 10.1016/j.biochi.2010.03.004. Epub 2010 Mar 29.
Biochimie. 2010.
PMID: 20353808
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Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis.
Dobson RC, Perugini MA, Jameson GB, Gerrard JA.
Dobson RC, et al.
Biochimie. 2009 Aug;91(8):1036-44. doi: 10.1016/j.biochi.2009.05.013. Epub 2009 Jun 6.
Biochimie. 2009.
PMID: 19505526
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Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme.
Pearce FG, Dobson RC, Weber A, Lane LA, McCammon MG, Squire MA, Perugini MA, Jameson GB, Robinson CV, Gerrard JA.
Pearce FG, et al.
Biochemistry. 2008 Nov 18;47(46):12108-17. doi: 10.1021/bi801094t. Epub 2008 Oct 21.
Biochemistry. 2008.
PMID: 18937497
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Evolution of quaternary structure in a homotetrameric enzyme.
Griffin MD, Dobson RC, Pearce FG, Antonio L, Whitten AE, Liew CK, Mackay JP, Trewhella J, Jameson GB, Perugini MA, Gerrard JA.
Griffin MD, et al.
J Mol Biol. 2008 Jul 18;380(4):691-703. doi: 10.1016/j.jmb.2008.05.038. Epub 2008 May 22.
J Mol Biol. 2008.
PMID: 18556019
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Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase.
Dobson RC, Devenish SR, Turner LA, Clifford VR, Pearce FG, Jameson GB, Gerrard JA.
Dobson RC, et al.
Biochemistry. 2005 Oct 4;44(39):13007-13. doi: 10.1021/bi051281w.
Biochemistry. 2005.
PMID: 16185069
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The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad.
Dobson RC, Valegård K, Gerrard JA.
Dobson RC, et al.
J Mol Biol. 2004 Apr 23;338(2):329-39. doi: 10.1016/j.jmb.2004.02.060.
J Mol Biol. 2004.
PMID: 15066435
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