Structural and Biochemical Characterization of 6-Hydroxynicotinic Acid 3-Monooxygenase, A Novel Decarboxylative Hydroxylase Involved in Aerobic Nicotinate Degradation

Biochemistry. 2016 Jun 21;55(24):3432-46. doi: 10.1021/acs.biochem.6b00105. Epub 2016 Jun 8.

Authors

Katherine A Hicks¹, Meigan E Yuen¹, Wei Feng Zhen¹, Tyler J Gerwig², Ryan W Story², Megan C Kopp³, Mark J Snider²

Affiliations

¹ Department of Chemistry, SUNY Cortland , Cortland, New York 13045, United States.
² Department of Chemistry, The College of Wooster , Wooster, Ohio 44691, United States.
³ Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States.

PMID: 27218267
DOI: 10.1021/acs.biochem.6b00105

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aerobiosis
Bacteria / enzymology*
Bacteria / genetics
Bacterial Proteins / chemistry*
Bacterial Proteins / genetics
Bacterial Proteins / metabolism
Crystallography, X-Ray
Hydroxylation
Mixed Function Oxygenases / chemistry*
Mixed Function Oxygenases / genetics
Mixed Function Oxygenases / metabolism
Niacin / chemistry*
Niacin / metabolism
Protein Domains

Substances

Bacterial Proteins
Niacin
Mixed Function Oxygenases
6-hydroxynicotinate 3-monooxygenase

Grants and funding