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Structure-based identification of a potential non-catalytic binding site for rational drug design in the fructose 1,6-biphosphate aldolase from Giardia lamblia.
Sci Rep. 2019 Aug 13;9(1):11779. doi: 10.1038/s41598-019-48192-3.
Sci Rep. 2019.
PMID: 31409864
Free PMC article.
Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase.
Li Z, Liu Z, Cho DW, Zou J, Gong M, Breece RM, Galkin A, Li L, Zhao H, Maestas GD, Tierney DL, Herzberg O, Dunaway-Mariano D, Mariano PS.
Li Z, et al.
J Inorg Biochem. 2011 Apr;105(4):509-17. doi: 10.1016/j.jinorgbio.2010.12.012. Epub 2010 Dec 30.
J Inorg Biochem. 2011.
PMID: 21333622
Free PMC article.
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Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolase.
Galkin A, Li Z, Li L, Kulakova L, Pal LR, Dunaway-Mariano D, Herzberg O.
Galkin A, et al.
Biochemistry. 2009 Apr 14;48(14):3186-96. doi: 10.1021/bi9001166.
Biochemistry. 2009.
PMID: 19236002
Free PMC article.
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Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia.
Galkin A, Kulakova L, Melamud E, Li L, Wu C, Mariano P, Dunaway-Mariano D, Nash TE, Herzberg O.
Galkin A, et al.
J Biol Chem. 2007 Feb 16;282(7):4859-4867. doi: 10.1074/jbc.M609534200. Epub 2006 Dec 13.
J Biol Chem. 2007.
PMID: 17166851
Free article.
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