Abstract
Co-crystallization of a 2 kDa tether-free sulfonated foldamer and the 13 kDa lysine-rich cytochrome c yielded a remarkable biohybrid assembly with chiral resolution of the foldamer helix handedness. In the crystal a ∼5 nm foldamer stack was surrounded by eight molecules of protein. NMR and CD experiments suggest interesting differences in the solution state recognition processes.
MeSH terms
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Circular Dichroism
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Crystallization
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Crystallography, X-Ray
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Cytochromes c / chemistry
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Cytochromes c / metabolism*
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Indoles / chemical synthesis
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Indoles / chemistry
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Indoles / metabolism
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Ligands
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Magnetic Resonance Spectroscopy
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Polymers / chemical synthesis
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Polymers / chemistry
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Polymers / metabolism*
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Protein Binding
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Pyridines / chemical synthesis
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Pyridines / chemistry
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Pyridines / metabolism
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Saccharomyces cerevisiae / enzymology
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Saccharomyces cerevisiae Proteins / chemistry
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Saccharomyces cerevisiae Proteins / metabolism*
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Stereoisomerism
Substances
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Indoles
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Ligands
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Polymers
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Pyridines
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Saccharomyces cerevisiae Proteins
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Cytochromes c