Abstract
1,4-Diaminobutanone, a competitive inhibitor of ornithine decarboxylase in Aspergillus nidulans, is able to increase the half-life of this enzyme and thus stimulate an increase in its activity in vivo. It also protects ornithine decarboxylase against proteolysis by chymotrypsin in vitro.
MeSH terms
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Aspergillus nidulans / enzymology*
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Butanones / pharmacology*
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Carboxy-Lyases / metabolism*
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Chymotrypsin / metabolism
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Cycloheximide / metabolism
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Enzyme Activation / drug effects
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Half-Life
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Ornithine Decarboxylase / metabolism*
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Putrescine / analogs & derivatives*
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Putrescine / pharmacology
Substances
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Butanones
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1,4-diaminobutanone
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Cycloheximide
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Chymotrypsin
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Carboxy-Lyases
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Ornithine Decarboxylase
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Putrescine