The effect of 1,4-diaminobutanone on the stability of ornithine decarboxylase from Aspergillus nidulans

Biochem J. 1977 Sep 15;166(3):635-7. doi: 10.1042/bj1660635.

Abstract

1,4-Diaminobutanone, a competitive inhibitor of ornithine decarboxylase in Aspergillus nidulans, is able to increase the half-life of this enzyme and thus stimulate an increase in its activity in vivo. It also protects ornithine decarboxylase against proteolysis by chymotrypsin in vitro.

MeSH terms

  • Aspergillus nidulans / enzymology*
  • Butanones / pharmacology*
  • Carboxy-Lyases / metabolism*
  • Chymotrypsin / metabolism
  • Cycloheximide / metabolism
  • Enzyme Activation / drug effects
  • Half-Life
  • Ornithine Decarboxylase / metabolism*
  • Putrescine / analogs & derivatives*
  • Putrescine / pharmacology

Substances

  • Butanones
  • 1,4-diaminobutanone
  • Cycloheximide
  • Chymotrypsin
  • Carboxy-Lyases
  • Ornithine Decarboxylase
  • Putrescine