Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets

Liang Wang; Wen-Tao Hou; Jie Wang; Da Xu; Cong Guo; Linfeng Sun; Ke Ruan; Cong-Zhao Zhou; Yuxing Chen

doi:10.1038/s41422-021-00611-9

Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets

Cell Res. 2022 May;32(5):501-504. doi: 10.1038/s41422-021-00611-9. Epub 2022 Jan 18.

Authors

Liang Wang^#^{1

2}, Wen-Tao Hou^#^{3

4}, Jie Wang^{1

2}, Da Xu^{1

2}, Cong Guo^{1

2}, Linfeng Sun^{1

2}, Ke Ruan^{1

2}, Cong-Zhao Zhou^{5

6}, Yuxing Chen^{7

8}

Affiliations

¹ The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
² School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
³ The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. todvince@mail.ustc.edu.cn.
⁴ School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. todvince@mail.ustc.edu.cn.
⁵ The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. zcz@ustc.edu.cn.
⁶ School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. zcz@ustc.edu.cn.
⁷ The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. cyxing@ustc.edu.cn.
⁸ School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. cyxing@ustc.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 11
Bile Acids and Salts*
Humans

Substances

ABCB11 protein, human
ATP Binding Cassette Transporter, Subfamily B, Member 11
Bile Acids and Salts