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Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect.
Nishiga Y, Drainas AP, Baron M, Bhattacharya D, Barkal AA, Ahrari Y, Mancusi R, Ross JB, Takahashi N, Thomas A, Diehn M, Weissman IL, Graves EE, Sage J. Nishiga Y, et al. Among authors: drainas ap. Nat Cancer. 2022 Nov;3(11):1351-1366. doi: 10.1038/s43018-022-00456-0. Epub 2022 Nov 21. Nat Cancer. 2022. PMID: 36411318 Free PMC article.
Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis.
Qu F, Brough SC, Michno W, Madubata CJ, Hartmann GG, Puno A, Drainas AP, Bhattacharya D, Tomasich E, Lee MC, Yang D, Kim J, Peiris-Pagès M, Simpson KL, Dive C, Preusser M, Toland A, Kong C, Das M, Winslow MM, Pasca AM, Sage J. Qu F, et al. Among authors: drainas ap. Nat Cell Biol. 2023 Oct;25(10):1506-1519. doi: 10.1038/s41556-023-01241-6. Epub 2023 Oct 2. Nat Cell Biol. 2023. PMID: 37783795
A multiplexed in vivo approach to identify driver genes in small cell lung cancer.
Lee MC, Cai H, Murray CW, Li C, Shue YT, Andrejka L, He AL, Holzem AME, Drainas AP, Ko JH, Coles GL, Kong C, Zhu S, Zhu C, Wang J, van de Rijn M, Petrov DA, Winslow MM, Sage J. Lee MC, et al. Among authors: drainas ap. Cell Rep. 2023 Jan 31;42(1):111990. doi: 10.1016/j.celrep.2023.111990. Epub 2023 Jan 13. Cell Rep. 2023. PMID: 36640300 Free PMC article.
The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.
Chaikovsky AC, Li C, Jeng EE, Loebell S, Lee MC, Murray CW, Cheng R, Demeter J, Swaney DL, Chen SH, Newton BW, Johnson JR, Drainas AP, Shue YT, Seoane JA, Srinivasan P, He A, Yoshida A, Hipkins SQ, McCrea E, Poltorack CD, Krogan NJ, Diehl JA, Kong C, Jackson PK, Curtis C, Petrov DA, Bassik MC, Winslow MM, Sage J. Chaikovsky AC, et al. Among authors: drainas ap. Nature. 2021 Apr;592(7856):794-798. doi: 10.1038/s41586-021-03474-7. Epub 2021 Apr 14. Nature. 2021. PMID: 33854239 Free PMC article.
Spatial epitope barcoding reveals clonal tumor patch behaviors.
Rovira-Clavé X, Drainas AP, Jiang S, Bai Y, Baron M, Zhu B, Dallas AE, Lee MC, Chu TP, Holzem A, Ayyagari R, Bhattacharya D, McCaffrey EF, Greenwald NF, Markovic M, Coles GL, Angelo M, Bassik MC, Sage J, Nolan GP. Rovira-Clavé X, et al. Among authors: drainas ap. Cancer Cell. 2022 Nov 14;40(11):1423-1439.e11. doi: 10.1016/j.ccell.2022.09.014. Epub 2022 Oct 13. Cancer Cell. 2022. PMID: 36240778 Free PMC article.
RB depletion is required for the continuous growth of tumors initiated by loss of RB.
Doan A, Arand J, Gong D, Drainas AP, Shue YT, Lee MC, Zhang S, Walter DM, Chaikovsky AC, Feldser DM, Vogel H, Dow LE, Skotheim JM, Sage J. Doan A, et al. Among authors: drainas ap. PLoS Genet. 2021 Dec 8;17(12):e1009941. doi: 10.1371/journal.pgen.1009941. eCollection 2021 Dec. PLoS Genet. 2021. PMID: 34879057 Free PMC article.
The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer.
Cristea S, Coles GL, Hornburg D, Gershkovitz M, Arand J, Cao S, Sen T, Williamson SC, Kim JW, Drainas AP, He A, Cam LL, Byers LA, Snyder MP, Contrepois K, Sage J. Cristea S, et al. Among authors: drainas ap. Cancer Res. 2020 Mar 15;80(6):1293-1303. doi: 10.1158/0008-5472.CAN-19-1027. Epub 2020 Jan 22. Cancer Res. 2020. PMID: 31969375 Free PMC article.
15 results