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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1978 1
1980 1
1981 1
1982 8
1983 13
1984 7
1985 8
1986 9
1987 3
1988 2
1991 1
1992 1
1993 2
1994 2
1995 2
1996 3
1997 5
1998 2
1999 4
2000 4
2001 2
2003 1
2004 1
2005 8
2006 12
2007 10
2008 10
2009 7
2010 10
2011 7
2012 6
2013 13
2014 14
2015 15
2016 10
2017 10
2018 7
2019 4
2020 9
2021 13
2022 11
2023 7
2024 2

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255 results

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Page 1
Organizing structural principles of the IL-17 ligand-receptor axis.
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC. Wilson SC, et al. Among authors: piehler j. Nature. 2022 Sep;609(7927):622-629. doi: 10.1038/s41586-022-05116-y. Epub 2022 Jul 21. Nature. 2022. PMID: 35863378 Free PMC article.
Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy.
Yang X, Nishimiya D, Löchte S, Jude KM, Borowska M, Savvides CS, Dougan M, Su L, Zhao X, Piehler J, Garcia KC. Yang X, et al. Among authors: piehler j. Nat Biotechnol. 2023 Jul;41(7):932-943. doi: 10.1038/s41587-022-01567-w. Epub 2023 Jan 2. Nat Biotechnol. 2023. PMID: 36593402 Free PMC article.
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.
Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC. Miao Y, et al. Among authors: piehler j. Cell Stem Cell. 2020 Nov 5;27(5):840-851.e6. doi: 10.1016/j.stem.2020.07.020. Epub 2020 Aug 19. Cell Stem Cell. 2020. PMID: 32818433 Free PMC article.
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. Gaggero S, et al. Among authors: piehler j. Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2. Sci Immunol. 2022. PMID: 36459543
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.
Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC. Janda CY, et al. Among authors: piehler j. Nature. 2017 May 11;545(7653):234-237. doi: 10.1038/nature22306. Epub 2017 May 3. Nature. 2017. PMID: 28467818 Free PMC article.
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Tsirigotaki A, Dansercoer A, Verschueren KHG, Marković I, Pollmann C, Hafer M, Felix J, Birck C, Van Putte W, Catteeuw D, Tavernier J, Fernando Bazan J, Piehler J, Savvides SN, Verstraete K. Tsirigotaki A, et al. Among authors: piehler j. Nat Struct Mol Biol. 2023 Apr;30(4):551-563. doi: 10.1038/s41594-023-00941-9. Epub 2023 Mar 23. Nat Struct Mol Biol. 2023. PMID: 36959263
255 results