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Whole-genome doubling confers unique genetic vulnerabilities on tumour cells.
Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. Quinton RJ, et al. Nature. 2021 Feb;590(7846):492-497. doi: 10.1038/s41586-020-03133-3. Epub 2021 Jan 27. Nature. 2021. PMID: 33505027 Free PMC article.
Whole-genome doubling in tissues and tumors.
Vittoria MA, Quinton RJ, Ganem NJ. Vittoria MA, et al. Among authors: quinton rj. Trends Genet. 2023 Dec;39(12):954-967. doi: 10.1016/j.tig.2023.08.004. Epub 2023 Sep 14. Trends Genet. 2023. PMID: 37714734 Review.
Identification of the kinase STK25 as an upstream activator of LATS signaling.
Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ. Lim S, et al. Among authors: quinton rj. Nat Commun. 2019 Apr 4;10(1):1547. doi: 10.1038/s41467-019-09597-w. Nat Commun. 2019. PMID: 30948712 Free PMC article.