Anti-sulfatide antibodies in HIV-infected individuals with sensory neuropathy

Neurology. 2005 May 10;64(9):1632-4. doi: 10.1212/01.WNL.0000160394.77818.AD.

Abstract

We used ELISA to estimate the prevalence of anti-sulfatide antibodies in HIV-infected individuals with distal sensory neuropathy (DSP) and compared the results with the prevalence in HIV-infected individuals without DSP and in individuals with neuropathy who are not infected with HIV. We found that 36% of HIV+/DSP+ individuals had immunoglobulin (Ig) G anti-sulfatide antibody titers greater than 1,500, whereas IgG anti-sulfatide antibodies were rarely found in HIV+/DSP- or HIV-/DSP+ patients.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Autoantibodies / blood*
  • Enzyme-Linked Immunosorbent Assay / methods
  • HIV Infections / blood
  • HIV Infections / complications
  • HIV Infections / immunology*
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / immunology
  • Neuralgia / etiology
  • Paresthesia / etiology
  • Peripheral Nervous System Diseases / blood
  • Peripheral Nervous System Diseases / complications
  • Peripheral Nervous System Diseases / immunology*
  • Predictive Value of Tests
  • Sulfoglycosphingolipids / immunology*

Substances

  • Autoantibodies
  • Immunoglobulin G
  • Sulfoglycosphingolipids