Abstract
We used ELISA to estimate the prevalence of anti-sulfatide antibodies in HIV-infected individuals with distal sensory neuropathy (DSP) and compared the results with the prevalence in HIV-infected individuals without DSP and in individuals with neuropathy who are not infected with HIV. We found that 36% of HIV+/DSP+ individuals had immunoglobulin (Ig) G anti-sulfatide antibody titers greater than 1,500, whereas IgG anti-sulfatide antibodies were rarely found in HIV+/DSP- or HIV-/DSP+ patients.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Autoantibodies / blood*
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Enzyme-Linked Immunosorbent Assay / methods
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HIV Infections / blood
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HIV Infections / complications
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HIV Infections / immunology*
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Humans
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Immunoglobulin G / blood
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Immunoglobulin G / immunology
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Neuralgia / etiology
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Paresthesia / etiology
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Peripheral Nervous System Diseases / blood
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Peripheral Nervous System Diseases / complications
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Peripheral Nervous System Diseases / immunology*
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Predictive Value of Tests
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Sulfoglycosphingolipids / immunology*
Substances
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Autoantibodies
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Immunoglobulin G
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Sulfoglycosphingolipids