Adenoviral infection presenting as an isolated central nervous system disease without detectable viremia in two children after stem cell transplantation

J Clin Microbiol. 2011 Jun;49(6):2361-4. doi: 10.1128/JCM.00080-11. Epub 2011 Apr 13.

Abstract

We report two cases of adenoviral meningoencephalitis in children following allogeneic stem cell transplantation. These cases showed four similarities: isolated neurological involvement, infiltrating hyperintensities next to the third ventricle on the cerebral magnetic resonance image, the absence of concomitant detectable adenoviral viremia, and a severe clinical outcome.

Publication types

  • Case Reports

MeSH terms

  • Adenoviridae Infections / diagnosis*
  • Adenoviridae Infections / virology
  • Adenoviruses, Human / isolation & purification*
  • Adolescent
  • Blood / virology
  • Brain / diagnostic imaging
  • Cerebrospinal Fluid / virology
  • Child
  • Female
  • Humans
  • Immunocompromised Host
  • Infant
  • Magnetic Resonance Imaging
  • Meningoencephalitis / diagnosis*
  • Meningoencephalitis / virology
  • Radiography
  • Stem Cell Transplantation / adverse effects*