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LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Sloan M, Alegre-Abarrategui J, Potgieter D, Kaufmann AK, Exley R, Deltheil T, Threlfell S, Connor-Robson N, Brimblecombe K, Wallings R, Cioroch M, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Dodson PD, Wade-Martins R. Sloan M, et al. Hum Mol Genet. 2016 Mar 1;25(5):951-63. doi: 10.1093/hmg/ddv628. Epub 2016 Jan 6. Hum Mol Genet. 2016. PMID: 26744332 Free PMC article.
Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits.
Simanaviciute U, Ahmed J, Brown RE, Connor-Robson N, Farr TD, Fertan E, Gambles N, Garland H, Morton AJ, Staiger JF, Skillings EA, Trueman RC, Wade-Martins R, Wood NI, Wong AA, Grant RA. Simanaviciute U, et al. J Neurosci Methods. 2020 Feb 1;331:108532. doi: 10.1016/j.jneumeth.2019.108532. Epub 2019 Nov 28. J Neurosci Methods. 2020. PMID: 31785300 Review.
"LRRK2: Autophagy and Lysosomal Activity".
Madureira M, Connor-Robson N, Wade-Martins R. Madureira M, et al. Front Neurosci. 2020 May 25;14:498. doi: 10.3389/fnins.2020.00498. eCollection 2020. Front Neurosci. 2020. PMID: 32523507 Free PMC article. Review.
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.
Bengoa-Vergniory N, Faggiani E, Ramos-Gonzalez P, Kirkiz E, Connor-Robson N, Brown LV, Siddique I, Li Z, Vingill S, Cioroch M, Cavaliere F, Threlfell S, Roberts B, Schrader T, Klärner FG, Cragg S, Dehay B, Bitan G, Matute C, Bezard E, Wade-Martins R. Bengoa-Vergniory N, et al. Among authors: connor robson n. Nat Commun. 2020 Sep 28;11(1):4885. doi: 10.1038/s41467-020-18689-x. Nat Commun. 2020. PMID: 32985503 Free PMC article.
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Roberts BM, Doig NM, Brimblecombe KR, Lopes EF, Siddorn RE, Threlfell S, Connor-Robson N, Bengoa-Vergniory N, Pasternack N, Wade-Martins R, Magill PJ, Cragg SJ. Roberts BM, et al. Among authors: connor robson n. Nat Commun. 2020 Oct 2;11(1):4958. doi: 10.1038/s41467-020-18247-5. Nat Commun. 2020. PMID: 33009395 Free PMC article.
27 results