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Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs.
Bijen HM, van der Steen DM, Hagedoorn RS, Wouters AK, Wooldridge L, Falkenburg JHF, Heemskerk MHM. Bijen HM, et al. Among authors: heemskerk mhm. Mol Ther. 2018 May 2;26(5):1206-1214. doi: 10.1016/j.ymthe.2018.02.017. Epub 2018 Feb 23. Mol Ther. 2018. PMID: 29567312 Free PMC article.
Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia.
Marijt WA, Heemskerk MH, Kloosterboer FM, Goulmy E, Kester MG, van der Hoorn MA, van Luxemburg-Heys SA, Hoogeboom M, Mutis T, Drijfhout JW, van Rood JJ, Willemze R, Falkenburg JH. Marijt WA, et al. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2742-7. doi: 10.1073/pnas.0530192100. Epub 2003 Feb 24. Proc Natl Acad Sci U S A. 2003. PMID: 12601144 Free PMC article.
Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region.
Heemskerk MH, Hoogeboom M, de Paus RA, Kester MG, van der Hoorn MA, Goulmy E, Willemze R, Falkenburg JH. Heemskerk MH, et al. Blood. 2003 Nov 15;102(10):3530-40. doi: 10.1182/blood-2003-05-1524. Epub 2003 Jul 17. Blood. 2003. PMID: 12869497 Free article.
Multiple myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene.
van Bergen CA, Kester MG, Jedema I, Heemskerk MH, van Luxemburg-Heijs SA, Kloosterboer FM, Marijt WA, de Ru AH, Schaafsma MR, Willemze R, van Veelen PA, Falkenburg JH. van Bergen CA, et al. Blood. 2007 May 1;109(9):4089-96. doi: 10.1182/blood-2006-08-043935. Epub 2007 Jan 18. Blood. 2007. PMID: 17234742 Free article. Clinical Trial.
165 results