Aciclovir-resistant herpes keratitis

Clin Exp Ophthalmol. 2010 Apr;38(3):309-13. doi: 10.1111/j.1442-9071.2010.02209.x.

Abstract

Herpes simplex virus (HSV) keratitis is a common cause of ocular morbidity. Resistance to aciclovir is probably under recognized. We describe three cases of aciclovir-resistant herpes simplex virus keratitis treated with systemic foscarnet and present a review of the pharmacological options available to manage this condition.

Publication types

  • Review

MeSH terms

  • Acyclovir / administration & dosage
  • Acyclovir / therapeutic use*
  • Administration, Oral
  • Administration, Topical
  • Aged, 80 and over
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use*
  • Blindness / virology
  • Drug Resistance, Viral*
  • Humans
  • Keratitis, Herpetic / complications
  • Keratitis, Herpetic / drug therapy*
  • Male
  • Middle Aged
  • Treatment Outcome

Substances

  • Antiviral Agents
  • Acyclovir