Hyperexcitability in the neural substrate of emotional behavior in cats after alcohol withdrawal. Evidence of a rapid development of alcohol dependence

J Stud Alcohol. 1975 Nov;36(11):1480-92. doi: 10.15288/jsa.1975.36.1480.

Abstract

Substantial and prolonged withdrawal hyperexcitability in the neural substrate for affective defense was revealed by behavioral and electrophysiological measures in cats exposed to moderate to heavy doses of alcohol for periods ranging from 6 to 72 hours. The data are interpreted as indicating a rapid development of physical dependence on alcohol in this portion of the central nervous system.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amygdala / drug effects
  • Amygdala / physiopathology*
  • Animals
  • Behavior, Animal / drug effects
  • Cats
  • Emotions / drug effects
  • Ethanol* / pharmacology
  • Female
  • Humans
  • Hypothalamus / physiopathology*
  • Hypothalamus, Middle / drug effects
  • Hypothalamus, Middle / physiopathology*
  • Substance Withdrawal Syndrome / physiopathology
  • Substance-Related Disorders / physiopathology*

Substances

  • Ethanol