alpha1-Microglobulin, a new low molecular weight plasma protein

Clin Chim Acta. 1976 Dec;73(3):415-22. doi: 10.1016/0009-8981(76)90142-x.

Abstract

A new low molecular weight protein was purified from the urine of uraemic patients. The protein was found to be glycoprotein with a molecular weight of 31 500, determined by SDS-polyacrylamide gel electrophoresis, and a carbohydrate content of 19%. It was electrophoretically heterogenous and migrated in the slow alpha1-region. The mean serum level in 20 apparently healthy individuals was 32+/-10 mg/1. The serum level was normal in 5 patients with severe reduction of plasma protein synthesis caused by cirrhosis of the liver but elevated in patients with a decreased glomerular filtration rate. The mean urinary excretion in 5 healthy individuals was 1.3 mg/24 h. Increased excretion was seen in 10 patients with varying degrees of uraemia.

MeSH terms

  • Amino Acids / analysis
  • Electrophoresis, Polyacrylamide Gel
  • Glomerular Filtration Rate
  • Hexosamines / analysis
  • Hexoses / analysis
  • Humans
  • Immunoelectrophoresis, Two-Dimensional
  • Kidney Diseases / blood
  • Liver Cirrhosis / blood
  • Molecular Weight
  • Serum Globulins / metabolism*
  • Serum Globulins / urine
  • Sialic Acids / analysis
  • Uremia / blood
  • Uremia / metabolism*
  • Uremia / urine

Substances

  • Amino Acids
  • Hexosamines
  • Hexoses
  • Serum Globulins
  • Sialic Acids