C-peptide in children with juvenile diabetes. A preliminary report

Diabetologia. 1976 Dec;12(6):627-30. doi: 10.1007/BF01220642.


Serum C-peptide, insulin-binding IgG and total insulin (IRI) were determined in 96 juvenile diabetics aged 4-21 years, with onset of diabetes at the age of 1-16 years and with 2-17 years' duration of diabetes. Thirty-four patients (35.4%) had detectable levels of C-peptide (greater than or equal to 0.04 pmol/ml). Compared to non-diabetic adults, 19 had values below the normal range, 12 showed values within the normal range (0.18-0.63 pmol/ml) and 3 rated above normal. There was a negative correlation between the fasting C-peptide concentration and the degree of ketonuria at the onset of diabetes and a positive correlation between C-peptide levels and the incidence of post-initial remission periods. Patients without detectable C-peptide had significantly higher levels of insulin antibodies than those who had detectable levels of C-peptide. The possibility of a relationship between the intensity of the initial treatment of diabetes and the preservation of the B-cell function is discussed, as well as the possibility of insulin antibodies being a cause of B-cell exhaustion.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • C-Peptide / blood*
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1 / blood*
  • Diabetes Mellitus, Type 1 / drug therapy
  • Humans
  • Insulin / therapeutic use
  • Insulin Antibodies / analysis
  • Ketone Bodies / urine
  • Peptides / blood*
  • Remission, Spontaneous


  • C-Peptide
  • Insulin
  • Insulin Antibodies
  • Ketone Bodies
  • Peptides