Intracellular signalling: PDK1--a kinase at the hub of things

Curr Biol. 1999 Feb 11;9(3):R93-6. doi: 10.1016/s0960-9822(99)80058-x.

Abstract

Phosphoinositide-dependent kinase 1 (PDK1) is at the hub of many signalling pathways, activating PKB and PKC isoenzymes, as well as p70 S6 kinase and perhaps PKA. PDK1 action is determined by colocalization with substrate and by target site availability, features that may enable it to operate in both resting and stimulated cells.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • 3-Phosphoinositide-Dependent Protein Kinases
  • Amino Acid Sequence
  • Animals
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Enzyme Activation
  • Humans
  • Isoenzymes / metabolism
  • Molecular Sequence Data
  • Phosphatidylinositols / physiology*
  • Phosphorylation
  • Protein Kinase C / chemistry
  • Protein Kinase C / metabolism
  • Protein Processing, Post-Translational*
  • Protein-Serine-Threonine Kinases / chemistry
  • Protein-Serine-Threonine Kinases / physiology*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-akt
  • Ribosomal Protein S6 Kinases / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Signal Transduction / physiology*

Substances

  • Isoenzymes
  • Phosphatidylinositols
  • Proto-Oncogene Proteins
  • 3-Phosphoinositide-Dependent Protein Kinases
  • PDPK1 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Ribosomal Protein S6 Kinases
  • Cyclic AMP-Dependent Protein Kinases
  • Protein Kinase C