How does radiation kill cells?

Curr Opin Chem Biol. 1999 Feb;3(1):77-83. doi: 10.1016/s1367-5931(99)80014-3.


Recent advances in the understanding of intracellular signaling after genotoxic injury have led to a better understanding of the pathways that influence radiation-induced cell death. Particular progress has been made in defining molecular controls of apoptosis and radiation-induced cell cycle arrest, as well as the possible role of telomerase activity in stabilizing DNA breaks.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / radiation effects
  • Cell Death / radiation effects*
  • Cell Membrane / radiation effects
  • DNA / radiation effects
  • Humans


  • DNA