How do peptide synthetases generate structural diversity?

Chem Biol. 1999 Feb;6(2):R39-48. doi: 10.1016/S1074-5521(99)80002-7.


Many low-molecular-weight peptides of microbial origin are synthesized nonribosomally on large multifunctional proteins, termed peptide synthetases. These enzymes contain repeated building blocks in which several defined domains catalyze specific reactions of peptide synthesis. The order of these domains within the enzyme determines the sequence and structure of the peptide product.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Peptide Biosynthesis / physiology*
  • Peptide Synthases / genetics
  • Peptide Synthases / metabolism*
  • Peptides / chemistry*
  • Protein Conformation


  • Peptides
  • Peptide Synthases