Orally administered proteases in aesthetic surgery

Aesthetic Plast Surg. Jan-Feb 1999;23(1):41-4. doi: 10.1007/s002669900241.


Increasing demand for shortening the sequel period after aesthetic surgery has led to comparative testing of optional approaches. Systemic enzyme therapy with its pharmacological effects represents a preventive and curative option for inflammatory process including healing. Excellent results were presented, namely, in the treatment of secondary lymphoedema. The incidence of hematoma, edema, and pain was followed, and the results were compared in a randomized group of 20 patients with upper eyelid blepharoplasty treated with proteases (Wobenzym drg) and in a similar group treated with systemic antiedema and hemostyptic therapy (Dicynone drg and Reparil drg). No undesirable side effects were observed. In addition, proteases apparently have no limitation for patients with the risk of concurrent cardiovascular, hepatic, or renal diseases.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Blepharoplasty*
  • Drug Combinations
  • Escin / administration & dosage
  • Ethamsylate / administration & dosage
  • Hemostatics / administration & dosage
  • Humans
  • Hydrolases / administration & dosage*
  • Middle Aged
  • Postoperative Care
  • Postoperative Complications / prevention & control*
  • Prospective Studies
  • Rutin / administration & dosage*


  • Drug Combinations
  • Hemostatics
  • Ethamsylate
  • Rutin
  • Escin
  • Wobenzym
  • Hydrolases