Use of cyproheptadine to control urine spraying and masturbation in a cat

J Am Vet Med Assoc. 1999 Feb 1;214(3):369-71, 351-2.


A 5-year-old male domestic longhair cat was examined because of urine spraying and masturbation. The cat had sprayed urine from the time it was acquired as a stray 4 years earlier. The cat was cryptorchid, and at 1 year of age, the scrotal testicle was removed. The cryptorchid testicle was surgically removed several months later; however, urine spraying and masturbation persisted. A diagnosis of territorial marking and separation anxiety was made. Serum testosterone concentration was within the reference range for sexually intact male cats. Treatment included behavior modification and administration of cyproheptadine (2 mg, p.o., q 12 h), which has been shown to have antiandrogenic effects in other species. Frequency of urine marking and masturbation decreased, along with serum testosterone concentration. The cat continued to do well as long as medication was given consistently. Eventually, the cat underwent a laparotomy for removal of remnant testicular tissues but was then lost to follow-up.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Cat Diseases / drug therapy*
  • Cats
  • Cyproheptadine / pharmacology
  • Cyproheptadine / therapeutic use*
  • Histamine H1 Antagonists / pharmacology
  • Histamine H1 Antagonists / therapeutic use*
  • Male
  • Masturbation / drug therapy
  • Serotonin Antagonists / pharmacology
  • Serotonin Antagonists / therapeutic use*
  • Urination Disorders / drug therapy
  • Urination Disorders / veterinary


  • Histamine H1 Antagonists
  • Serotonin Antagonists
  • Cyproheptadine