Leukotriene-receptor antagonists

Lancet. 1999 Jan 2;353(9146):57-62. doi: 10.1016/S0140-6736(98)09019-9.

Abstract

Leukotriene-receptor antagonists are the first novel class of antiasthma drugs to become available over the past three decades. They have an unique profile in that they are a hybrid of an anti-inflammatory and bronchodilator drug, and they can be taken as a tablet once or twice daily. The published data with leukotriene-receptor antagonists such as montelukast or zafirlukast show good antiasthmatic activity over a wide spectrum of asthma severity either as monotherapy or with inhaled steroids. Another potential spin-off of leukotriene-receptor antagonists is that they also seem to be effective in treating allergic rhinitis, which commonly coexists in patients with asthma. Here I overview the clinical pharmacology of leukotriene antagonists and appraise the published data from clinical trials, and look at the appropriate position of these agents in asthma management guidelines.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Acetates / administration & dosage
  • Acetates / adverse effects
  • Acetates / therapeutic use*
  • Adolescent
  • Adult
  • Anti-Asthmatic Agents / administration & dosage
  • Anti-Asthmatic Agents / adverse effects
  • Anti-Asthmatic Agents / therapeutic use*
  • Asthma / drug therapy*
  • Child
  • Drug Administration Schedule
  • Humans
  • Leukotriene Antagonists / administration & dosage
  • Leukotriene Antagonists / adverse effects
  • Leukotriene Antagonists / therapeutic use*
  • Quinolines / administration & dosage
  • Quinolines / adverse effects
  • Quinolines / therapeutic use*
  • Randomized Controlled Trials as Topic
  • Rhinitis, Allergic, Perennial / drug therapy
  • Rhinitis, Allergic, Perennial / physiopathology
  • Tosyl Compounds / administration & dosage
  • Tosyl Compounds / adverse effects
  • Tosyl Compounds / therapeutic use*

Substances

  • Acetates
  • Anti-Asthmatic Agents
  • Leukotriene Antagonists
  • Quinolines
  • Tosyl Compounds
  • montelukast
  • zafirlukast