Steroid-responsive multifocal demyelinating neuropathy with central involvement

Muscle Nerve. 1999 Feb;22(2):262-5. doi: 10.1002/(sici)1097-4598(199902)22:2<262::aid-mus16>;2-1.


We describe 2 patients with associated central and peripheral demyelination. Electrophysiological studies revealed a demyelinating polyneuropathy with sensory and motor conduction blocks. Visual evoked potentials were abnormal. Motor evoked potentials showed abnormal central conduction time in 1 patient. Magnetic resonance imaging revealed regions of abnormal high signal in the spinal cord and brain; sural nerve biopsy disclosed a demyelinating neuropathy. Both patients showed clinical and electrophysiological improvement after steroid therapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Central Nervous System Diseases / drug therapy
  • Central Nervous System Diseases / physiopathology*
  • Demyelinating Diseases / drug therapy
  • Demyelinating Diseases / physiopathology*
  • Electrodiagnosis
  • Evoked Potentials, Motor / physiology
  • Evoked Potentials, Somatosensory / physiology
  • Evoked Potentials, Visual / physiology
  • Female
  • Glucocorticoids / therapeutic use*
  • Humans
  • Male
  • Methylprednisolone / therapeutic use*
  • Middle Aged
  • Prednisone / therapeutic use*


  • Glucocorticoids
  • Prednisone
  • Methylprednisolone