Baker's asthma due to the enzyme xylanase -- a new occupational allergen

Clin Exp Allergy. 1998 Dec;28(12):1591-3. doi: 10.1046/j.1365-2222.1998.00429.x.


The asthmatic baker showed IgE-mediated sensitization to xylanase of Aspergillus niger used as a baking additive. Inhalative challenge with approximately 0.5 microg of the enzyme resulted in an immediate-type asthmatic reaction. This case, as well as a preliminary screening of symptomatic bakers, shows that xylanase is a further relevant type I-sensitizer in the baking industry.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intranasal
  • Adult
  • Aspergillus niger / enzymology
  • Asthma / etiology*
  • Asthma / pathology
  • Humans
  • Immunoglobulin E / analysis
  • Male
  • Occupational Diseases / immunology*
  • Xylan Endo-1,3-beta-Xylosidase
  • Xylosidases / immunology*


  • Immunoglobulin E
  • Xylosidases
  • Xylan Endo-1,3-beta-Xylosidase