Localized proton MRS of the human hippocampus: metabolite concentrations and relaxation times

Magn Reson Med. 1999 Jan;41(1):204-7. doi: 10.1002/(sici)1522-2594(199901)41:1<204::aid-mrm29>3.0.co;2-7.


Absolute concentrations and proton relaxation times of major metabolites in the human hippocampus were determined with use of fully relaxed, short-echo time STEAM localization sequences at 2.0 T (20 normal adults). Mean metabolite concentrations were 7.6+/-0.9 mM for total Nacetylaspartate (tNAA), 6.9+/-0.8 mM for total creatine (tCr), 2.1+/-0.3 mM for choline-containing compounds (Cho), and 6.2+/-0.9 mM for myo-inositol (Ins). The observation of relatively low tNAA and high Cho and Ins levels compared with cortical gray and white matter corresponds to a lower neuronal density and higher glial density than in the neocortex, in agreement with histologic findings. The data do not support a lateralization of metabolites. T1 and T2 relaxation times were in the range of 1400-1730 and 140-330 msec, respectively, similar to those in other brain regions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / metabolism
  • Biomarkers
  • Choline / metabolism*
  • Creatine / metabolism*
  • Epilepsy, Temporal Lobe / metabolism
  • Female
  • Hippocampus / metabolism*
  • Humans
  • Magnetic Resonance Spectroscopy / methods*
  • Male


  • Biomarkers
  • Aspartic Acid
  • N-acetylaspartate
  • Creatine
  • Choline