Detection of human papillomavirus type 10 DNA in eccrine syringofibroadenomatosis occurring in Clouston's syndrome

J Am Acad Dermatol. 1999 Feb;40(2 Pt 1):259-62. doi: 10.1016/s0190-9622(99)70201-x.


Syringofibroadenomatosis is often associated with an underlying condition such as diabetes mellitus or hidrotic ectodermal dysplasia. By reason of these associations, a reactive or hamartomatous cause is suspected. We report a case of a 71-year-old woman with Clouston's syndrome in whom progressive multiple palmoplantar syringofibroadenomas developed over a 10-year period. The syringofibroadenomas formed flat-topped papules simulating verruca plana; the widespread distribution and chronic progressive course resembled epidermodysplasia verruciformis. Contiguous with the syringofibroadenoma's characteristic epithelial-stromal proliferation were epidermal changes of verruca plana. Evidence of human papillomavirus (HPV) infection was verified by immunolabeling with antibodies to bovine papillomavirus type 1 and detection of HPV 10 viral DNA by means of polymerase chain reaction. Rather than a hamartomatous process, these findings suggest that syringofibroadenomas occurring in the setting of Clouston's syndrome could represent an HPV-induced epithelial proliferation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • DNA, Viral / analysis
  • Ectodermal Dysplasia / diagnosis
  • Ectodermal Dysplasia / virology*
  • Female
  • Humans
  • Papillomaviridae / genetics
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections / diagnosis
  • Papillomavirus Infections / virology*
  • Sweat Gland Neoplasms / diagnosis
  • Sweat Gland Neoplasms / virology*
  • Syringoma / diagnosis
  • Syringoma / virology*
  • Tumor Virus Infections / diagnosis
  • Tumor Virus Infections / virology*


  • DNA, Viral